- A Case of Concurrent Chemoradiation Therapy for Locally Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis
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Tae Young Yang, Suk Pyo Shin, Joo Ho Lee, Yun Bin Lee, Hana Park, Seong Gyu Hwang, Kyu Sung Rim
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J Liver Cancer. 2015;15(1):52-56. Published online March 31, 2015
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DOI: https://doi.org/10.17998/jlc.15.1.52
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 Abstract
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- Patients with advanced hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT)
have an extremely poor prognosis. Although the Barcelona Clinic Liver Cancer guideline
recommends sorafenib in advanced HCC with PVT, which has provided survival benefits of
2 or 3 months compared to the placebo group, many liver cancer centers in Asia still select
multimodality approaches including transarterial chemoembolization, radiofrequency
ablation, radiation therapy (RT) as well as systemic/intra-arterial chemotherapy. Recently
advanced RT technologies have shown potential to improve survival without severe radiationrelated
toxicity. For locally advanced HCC patients with PVT, concurrent chemoradiotherapy
(CCRT) has been applied as a loco-regional treatment and provides potential cures. We herein
report our recent experience of a patient accompanying large HCC with PVT who successfully
undergone CCRT followed by hepatic arterial infusion chemotherapy.
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THE KOREAN LIVER CANCER ASSOCIATION
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